Follow us on




Q of the week

Q: How Do You Get Shingles?

Get the Answer: 

Crohn's disease

Crohn's disease is an ongoing condition that causes inflammation of the digestive tract, or the GI (gastrointestinal) tract (the gut).

 Forums
Welcome Guest   [Register]  [Login]
EFGCP–EUCROF Joint Workshop Final Report   by  on 2010-08-20 20:12:20
Managing Clinical Trials   by  on 2010-07-16 00:05:32
US-FDA issues Revised Info Sheet Guidance on Clinical Investigator Disqualification   by  on 2010-06-13 18:11:41
US-FDA issues final guidance on Statement of Investigator (Form FDA 1572)   by  on 2010-06-13 18:07:59
Rising Clinical Trial Complexity Continues to Vex Drug Developers   by  on 2010-06-03 17:36:33
Investigator-Driven Clinical Trials: An ESF Forward Look   by  on 2010-06-03 17:27:58
NIH's Financial Conflict of Interest (FCOI) Proposed Rule   by  on 2010-05-27 19:42:00
AAP’s Guidelines for the Ethical Conduct of Studies to Evaluate Drugs in Pediatric Population   by  on 2010-05-13 19:39:54
Argentina: ANMAT - new regulatory update   by  on 2010-05-01 09:40:32
The Wall Street Journal's special supplement on clinical trials   by  on 2010-05-01 09:31:52
Major developments in EU Clinical Trial Guidances   by  on 2010-04-21 03:10:55
Analysis of the adverse reactions induced by natural product-derived drugs   by  on 2010-04-19 07:16:06
Newer Antibacterial Drugs for a New Century   by  on 2010-04-19 06:49:47
Newer Non-Statin Drugs for Reducing Cholesterol   by  on 2010-04-13 15:57:20
Practice Guidelines for Chronic Pain Management   by  on 2010-04-05 04:52:16
CONSORT III (2010)   by  on 2010-03-29 20:53:28
US FDA Draft Guidance on Pharmacokinetics in Patients with Impaired Renal Function   by  on 2010-03-20 20:25:16
US-FDA issues First Draft Guidance on Noninferiority Trials   by  on 2010-03-04 22:07:46
US FDA new rule on reporting information regarding falsification of data   by  on 2010-02-26 04:47:33
US-FDA Guidance for the Use of Bayesian Statistics in Medical Device Clinical Trials   by  on 2010-02-06 20:12:14
 Subject :Historical Events in Clinical Research: Part I.. 2009-10-14 19:22:45 
Sathvika
Newbie
Joined: 2009-07-28 23:25:14
Posts: 20
Location
2737 BCE: Shen-nung pen ts'ao ching (Divine Husbandman's Medical Materials) describes 365 medicines derived from minerals, plants and animals; believed to be authored by Shen Nung, the "father of Chinese medicine."

~600 BCE: Daniel designs and participates in a controlled nutritional study in the court of Nebuchadnezzar II, King of Babylon. Study is reported in the Old Testament sometime later.

400-200 BCE: Charaka Samhita, a textbook in verse of Ayurvedic medicine, is written in India.

~400 BCE: Hippocratic Oath defines responsibilities of physicians to their patients (with no mention of experimentation). Hippocrates, who lived in Greece probably sometime between 460 and 380 BCE, probably did not write the oath.

280 BCE: City of Alexandria gives Greek physician Herophilus and his colleague Erasistratus permission to cut into and look inside a prisoner condemned to death, for purposes of scientific investigation.

~200 BCE: Sushruta Samhita, a textbook in verse of Ayurvedic surgery, is written in India.

137 BCE: Attalus III (Philometer), King of Pergamum, tests the effects of extracts from poisonous plants by offering them in beverages to his guests.

162: Galen moves to Rome, where he develops the science of experimental physiology.

~550: Babylonian Talmud (Niddah (30b)) tells story about Cleopatra, who, to settle an argument between two rabbis about how long it takes for male and female fetuses to develop, had slave girls impregnated and operated on at specified times to examine the development of the fetuses. The investigators reported that boys developed in 40 days and girls took 80 days.

~930: Rhazes (Bakr Muhammad ibn Zakariyya al-Razi) publishes Kitab al-Hawi fi al-tibb (The Comprehensive Book of Medicine), in which he describes treating one group of patients with early symptoms of meningitis with bloodletting and another without, thereby determining that bloodletting prevents development of the disease.

~1030: Avicenna (Abū ‘Alī al-Husayn ibn ‘Abd Allāh ibn Sīnā), a Persian physician, publishes The Book of the Canon of Medicine (Qanun fi al-Tibb), setting forth seven rules for systematically evaluating the effect of drugs on diseases.

1061: Chinese government administrator Song Su publishes Ben Cao Tu Jing (Atlas of Materia Medica), a pharmacopeia.

~1175: Moses Maimonides, physician, writes prayer, including the line: "Inspire me with love for my art and for Thy creatures. Do not allow thirst for profit, ambition for renown and admiration, to interfere with my profession, for these are the enemies of truth and of love for mankind and they can lead astray in the great task of attending to the welfare of Thy creatures."

~1260: Roger Bacon, English scientist, philosopher, and Franciscan monk, writes that, "it is more difficult [for a physician] to [experiment] in [medical] science than in any other...because of the nobility of the material in which he works; for that body demands that no error be made in operating upon it…."

1500s: Paracelsus (Theophrastus Bombastus von Hohenheim), who traveled widely in Europe, teaches to investigate nature “not by following that which those of old taught, but by our own observation of nature, confirmed by… experiment and by reasoning thereon.”

1537: In the middle of a siege battle, physician Ambroise Paré of France runs out of boiling oil, the usual remedy for treating open wounds at the time, and discovers that treatment with a tincture of egg yolk, oil of rose, and turpentine reduces pain, swelling and mortality.

1662: Jan Baptist van Helmont, a Flemish medicinal chemist and disciple of Paracelsus, proposes a randomized test of his treatments vs. that of other physicians with 200 to 500 fever and pleurisy patients, backed by a wager of 300 florins that is not accepted.

1721: Sir Hans Sloane, physician to the King of England, hires Charles Maitland to inoculate six prisoners with smallpox. All were infected and survived to gain the reward of release from Newgate prison. Maitland subsequently demonstrated immunity for one of them.

1747: James Lind of Scotland conducts a study of the treatment of scurvy, assigning 12 sailors, in pairs, to citrus and five other potential treatments.

1759: Francis Home of Scotland tests measles “vaccine” (blood from a measles patient) in 12 children.
IP Logged
Last Edited On: 2009-10-14 19:22:45 By Sathvika for the Reason
Page # 


Powered by ccBoard